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Klipp og lim nr 1:
For the sake of simplicity, and to answer this question once and for all (I will keep bumping this post if need be)
THE BEST METHOD TO USE LIPODERM-Y IN A CUTTING PHASE
FOOD
1) Protein intake should be kept high, in order to sustain muscle mass. Take in, at least, 1 to 1.5 grams of protein per pound of body weight, each day, in divided meals
2) Carbohydrates should be restricted, to perpaps 1 gram per pound of body weight, the majority of which, should come from complex carbs, saving the higher glycemic carbs for POST WORKOUT USE ONLY.
3) Fat intake should be kept moderate, perhaps at .3 to.5 grams per pound of body weight, the majority of which should come from UNREFINED sources such as Flax seed oil, flax seeds, fish oil, fish, natural peanut butter, etc,,,
4) OVerall, your caloric intake should be kept approximatley 500-1000 calories below maintanece (edited, per Par's clarification), as the Lipoderm will liberate fatty acids, in which case, a deficit has to exist as such in order for the fat to be burned.
EXERCISE
1) Yes, as the laws of logic dictate, exercise is a necessity, for those that wish to diet, and to be in shape. Muscle tissue is metabolically active, and as such, the ability to maintain, or to build said muscle tissue will dictate your ability to burn calories.
2) Cardio is not neccessary, but it is helpful, although primary emphasis should be placed upon lifting weights, for the reason mentioned above. A more moderate volume should be used, with heavier weights, due to the lower stores of glycogen which will accompany a lower carb intake.
SUPPLEMENTS
1) If you wish, you make use of thermogenic, and ECA stacks, to enchance the utilization of the released fatty acids via Lipoderm.
There is a post, called Adipodkinetix Alternatives, which will explain, in detail, the various stack in which you may use with Lipoderm-y http://www.bodybuilding.com/forum/s...&threadid=14932
2) In addition to food, protein powders are helpful to take in lieu of meals. To keep this simple,
a) During the day, and before bed, it is best to use slower acting proteins such as calcium caseinate along with whey protein for sustained release
b) After a workout, it is best to use whey protein, with simple carbs, for the purpose of repair, and glycogen repletion.
LIPODERM-Y USAGE
1) This should be taken, 2 times per day, with 12 hours of separation in between.
2) This should be used at least 2 hours BEFORE, any activities in which you will sweat, or get the skin wet, for the yohimbine via Lipoderm will run off.
3) Use only 1 Large area at a time, or several small areas at a time, for the reason in which you can only utilize so many of the stored calories being released via Lipoderm, and if you release to many, those for which are not burned will be rediposited
nr 2:
Introduction:
I have previously stated that I believe transdermal prohormones to be the most effective supplements ever to hit the market. That statement must now be amended. Transdermal prohormones are indeed the most effective MUSCLE BUILDING supplements ever to hit the market. But, topical fat loss products have the potential to be an even bigger overall breakthrough in the never ending quest to improve body composition.
There are four areas that need to be addressed in regards to topical fat loss products and so called "spot reducers" in general.
First, one needs to distinguish between the products that are merely diuretics and those that the manufacturer (assuming they have a brain) actually thinks might significantly reduce body fat.
Second, we have to have an understanding of the andrenergic system, which is primarily what these products attempt to manipulate in order to aid lipolysis.
Third, we must have an understanding of transdermal/percutaneous delivery, in order to understand why a topical formulation could present advantages vs. orals, as well as to understand why nearly every product on the market fails miserably. Within this category there are two issues -- getting adequate amounts past the skin barrier and localizing its distribution to adipose tissue.
And, finally, there is the issue of Yohimbine HCl vs. yohimbe.
After reading this, you should have an understanding of why true "spot reduction" is physiologically quite possible, as well as enough information to make an informed decision as to which products can and cannot accomplish it.
Fat Loss Agents vs. Diuretics
Assuming we are not preparing for a photoshoot or competition, a product that merely acts as a diuretic rather than significantly aiding actual lipolysis is not what we want. "Cutting Gel" and "Dermalin-APg" belong in this category -- their active ingredient is aminophylline:
Aminophylline is a xanthine derivative, similar to caffeine, which, as we know, is not a particularly potent fat burner on its own. In rat studies, it has shown good thermogenic properties due to blockade of adenosine receptors (which provide one of the negative feedback mechanisms for catecholamine induced thermogenesis) and inhibition of phosphodiesterase (which degrade cyclic AMP) -- but this is at extremely high doses, which would kill a human, so it is not applicable (1,2). At therapeutic doses, only adenosine blockade occurs, which will act to increase norepinephrine levels (3)-- but as you will see, norepinephrine stimulates alpha 2 receptors (bad) in addition to beta 2 receptors (good) -- and in stubborn fat, alpha 2's outnumber beta 2's (4).
Like caffeine, aminophylline IS a good diuretic (5), which would account for the girth loss in the studies they reference, which did not measure actual fat loss (6,7). One study did look at fat depth after use of an aminophylline cream, and no difference was found vs. control (8). As a local diuretic, it is likely effective, but as a true fat loss agent, it quite likely is not. Such products WILL make you look more cut while you are taking them, but the true test of their efficacy is a week or two after you have stopped.
Products such as Avant Lab's LipoDerm-Y, Impact's DermaLean, and SAN's LipoBurn -- basically any of the products with yohimbine and a handful of other ingredients -- fall into the latter category. They are intended to manipulate the adrenergic system, thus such products could cause true localized fat loss if formulated properly (and since yohimbine tends to make you HOLD water, their true test is also a week or two after you have stopped).
The Adrenergic System
Introduction
One of the major contributors to body weight homeostasis in the human body is the adrenergic system. There are two types of adrenergic receptors, alpha and beta, as well as subtypes of each -- and depending on which are activated, lipolysis (breakdown of fat) can be either stimulated or inhibited.
The most well-known adrenoreceptors to bodybuilders are the beta receptors. These can be divided into subtypes 1, 2, and 3 -- and it is through these receptors that drugs such as the ephedrine/caffeine stack and Clenbuterol exert their effects. While Clenbuterol acts directly on beta 2 receptors, ephedrine exerts its effects indirectly by stimulating the release of norepinephrine (NE), the body's primary endogenous thermogenic hormone. Unlike Clenbuterol, NE is not selective in its binding. In addition to binding to the beta 2 receptor, it also binds to both alpha receptors, as well as the beta 1 and 3 receptors. It is in regards to its binding to the alpha 2 receptor that yohimbine comes into play.
Norepinephrine and Yohimbine
Activation of the alpha 2 receptor inhibits the release of NE. Thus, by binding to this receptor, NE functions as its own negative feedback signal. In other words, it shuts off its own release. Obviously, this is not a good thing for fat loss. This is particularly true at rest (which, unless you are a marathon runner is 95% of your day) -- this is because alpha 2 receptors are activated at lower catecholamine levels than are the beta receptors (9). Thus, thermogenesis is basically always turned off, particularly in areas with high alpha 2 densities.
There are regional differences in the distribution of alpha 2 and the beta receptors as well as gender differences -- this is what is responsible for the observed variations in bodyfat storage patterns(4). Basically, females tend to have a large number of alpha 2 receptors and few beta receptors in the gluteofemoral area (hips, thighs, and butt), while men have the same problem in the midsection. With exercise or the use of compounds such as the ephedrine/caffeine stack, catecholamine levels can be increased to a point where the alpha 2 induced inhibition of lipolysis is partially overcome (9). However, even then, the alpha 2 receptors ARE still acting to reduce lipolysis.
Yohimbine is a selective alpha 2 antagonist (10) and can thus short circuit this feedback loop, maximizing NE levels, thus maximizing fat loss, particularly in these problem areas -- and even more so if we can achieve high levels of yohimbine and NE in the adipose tissue. Unfortunately, to do so with orals, or any other method that results in high blood levels, means that we will also have high levels in the heart and CNS -- thus, we will also have unpleasant and dangerous side effects such as tachycardia, high blood pressure, and anxiety. Considering the subject of this article, I obviously believe the solution lies in transdermal administration -- but more on that in a bit.
Blood Flow
A second, more indirect, mechanism by which Yohimbine can aid lipolysis via the adrenergic system is by increasing peripheral blood flow (11, 12). Adipose tissue is known to have rather poor vascularity. When triglycerides are broken down into free fatty acids and glycerol during lipolysis, they must also be transported away from the fat cell or they risk being reincorporated into adipose tissue. Beta receptor activation causes vasodilation, thus increasing blood flow, however, it does not increase enough to remove all of the free fatty acids released during lipolysis (13). Alpha 1 and 2 receptor activation, on the other hand, causes a decrease in blood flow (4, 14). Thus, antagonism of the alpha 2 receptor with yohimbine would be expected to increase blood flow, and thus increase the mobilization and disposal of these FFA's, further aiding fat loss. And, again, the more we can get in the adipose tissue without it reaching the heart and CNS, the better.
Percutaneous Delivery
Though the terms are often used interchangeably in the literature, there are two distinct forms of drug delivery through the skin. The first, and most common, is "Transdermal Delivery" -- this involves a drug bypassing the skin barrier in order to be taken up into the bloodstream and distributed systemically (15). This basically does the same thing as oral delivery, but it is inherently time released and avoids first pass metabolism in the liver which can limit bioavailability and cause hepatotoxicity, so it is advantageous for delivering many drugs.
The second is "Percutaneous Delivery" (15)-- with this method, one bypasses the skin barrier, but with the purpose of delivering the drug to specific target tissues in the body, while AVOIDING uptake into the blood and subsequent systemic delivery. In the pharmaceutical realm, this has been pursued primarily for antibiotics and NSAIDS -- the former, to avoid destruction of systemic microflora (so-called "good bacteria"), and the latter to avoid hepatic recirculation, which is responsible for gastrointestinal problems.
Unfortunately, those who have developed most of the topical fat loss products thus far either do not know about or understand this difference, or they do not understand its PARAMOUNT importance in regards to adrenergic modulators such as yohimbine. With prohormones, systemic uptake and distribution is our goal -- they have poor oral bioavailability, so we are just trying to avoid the liver in order to get significant amounts in the bloodstream. However, with yohimbine and other adrenergic agents, oral bioavailabilty is not the issue -- at about 22%, it is more than adequate (16). We can readily achieve adequate blood levels with oral usage.
The issue with adrenergic modulators is that as we increase dosages (and thus blood levels) in order to increase distribution to adipose tissue to aid fat burning, we also increase distribution to the heart and CNS where we create numerous unwanted side effects such as rapid heart rate, high blood pressure, and overstimulation -- which become particularly noticeable with exercise. In addition, yohimbine is used clinically to produce anxiety (17). Ideally, we want our drug to reach fat cells in high concentrations, without the dangerous side effects of high levels in the heart and central nervous system, and this WILL NOT happen with typical transdermal delivery.
So, how do we do this?? Unfortunately, it is easier said the done. Typically, drugs that penetrate the skin barrier and traverse the epidermis and dermis are rapidly taken up by the dermal microvasculature, where they are delivered systemically (just like with orals) -- this is very well characterized in the literature (15,18,19) -- with direct tissue penetration being limited to 1-4 mm, which obviously is not exactly deep into the adipose tissue.
Let me repeat, if nothing is done to bypass the dermal microvasculature, our drug enters systemic circulation before it ever reaches the adipose tissue.
And, considering that these substances have good oral bioavailability, if the dermal microvasculature is not taken into account, we end up with a product that not only does not localize delivery, it does not even deliver it systemically as efficiently as an oral would do. Considering these products cost far more than there oral counterparts, and could also be thought of as inconvenient in that you have to rub them on your body, wait for them to dry, etc., any supplement developer who does not take dermal uptake into account has obviously missed the boat quite badly. And, guess what... There is only one product that does. And guess what else -- it will likely stay that way because a use patent has been filed on the one carrier that has been shown in the literature to effectively accomplish this.
Targeted Delivery
Let's now take a look at the literature that supports the idea of tissue specific delivery of therapeutic substances. As mentioned previously, when it comes to targeted delivery, the pharmaceutical realm, and thus the literature, has primarily concerned itself with antibiotics/anti-fungals and NSAIDS. We will look at the three most important ones.
The first study involved the NSAID indomethacin as the drug to be delivered. The drug was given orally (O) , topically without the "special delivery solvent" (WO), and with the "special delivery solvent" (W). The topicals were applied to the shoulder. For the first two hours after administration, concentrations of the drug in the deltoid (which is obviously even deeper than adipose tissue) were 5 times higher in W than in either O or WO. After 4 hours, it was 3 times as high, and by 8 hours it was still twice as high. Obviously, the formulation containing the "special delivery solvent" was vastly superior at delivering the drug to the target tissue. But what about delivery to unwanted tissues? If it was just a case of the "special delivery solvent" allowing more drug to cross the skin, this would not be a big deal -- we could just use more. What we also need is for a minimal amount of the drug to be delivered systemically, and once again, the "special delivery solvent" was shown to be superior. Maximal blood levels of all three compounds occurred at the 2 hour mark. W displayed levels about 1/3 that of O and 1/2 that of WO.
If the significance of this is not clear, it basically means that localized delivery (what we want) per unit systemic delivery (what we don't want) for W was 15 times that of O and 10 times that of WO -- and this was to the muscle. Considering the adipose tissue is closer to the skin (which had levels 10 times as high as the muscle) and that the joint capsule (which is below the muscle) had levels 1/3 that of the muscle while with WO there were equal levels at the muscle and joint, the ratio of delivery to adipose tissue vs. systemic delivery for W is likely quite a bit higher -- somewhere between 10 and 100 to 1.
The second study utilized the antibiotic erythromycin as the delivery drug. Formulations for W and WO were identical to the above study. Oral administration was not tested. Exact counts of the concentration in muscle tissue was not reported, but the authors stated that after 4 hours, there was a major increase in the muscle mass below the site of application. Kidney and liver levels (indicative of systemic distribution) were significantly lower for W than WO -- about 1/2 for the former and 1/4 for the latter over 24 hours.
The third study we will look at utilized the antifungal griseofulvin as the delivery drug and compared W with oral intake. The formulation for W was the same as the previous two studies. The accumulation of the active compound in the area of application for W was several HUNDREDFOLD greater than that which accumulated in the organs, and brain levels were non-detectable, which is extremely important considering we are trying to avoid excessive CNS stimulation -- and all of this was a full four days after application. Compare this to oral delivery which showed concentrations that were approximately identical in all areas (which would be expected if systemic uptake occurred).
Penetration Enhancement
I think it should be clear from the previous studies that it IS possible to achieve targeted delivery if the proper carrier is employed. However, if we cannot get adequate amounts of our substance past the skin barrier, it is a mute point. And, considering one of the skin's primary purposes is as a water barrier (20), hydrophilic substances such as yohimbine do not readily pass through (21, 22,23). Thus, we need to turn to the topic of penetration enhancement (for a more thorough presentation, see my previous article Transdermal Delivery.
Yohimbine HCl, with a LogP of about .75 (24), is fairly polar/hydrophilic, thus penetration enhancers should be chosen accordingly -- namely we want those which affect the polar route. This rules out many commonly employed penetration enhancers -- a fact many companies do not seem to be aware of. Since there is very little direct data on penetration enhancement with Yohimbine HCl, we will look at data when substances with similar physical properties were used.
One promising chemical in this area is the monoterpene, l-menthol. Polar molecules undergo significant hydrogen bonding in the stratum corneum, which is the primary reason for their poor passage through the skin barrier (23). Because of the presence of a hydroxyl (OH) group, l-menthol would be expected to bond to these hydrogens (25), leaving our drug free to more easily traverse the skin barrier. And, indeed the data has supported this. It increased the permeability coefficient of mannitol 100 fold vs. control (26). In a study using Propranolol HCl which has a partition coefficient almost identical to yohimbine (Log P .74 vs. .75), it increased flux 1000 fold vs. control and also displayed the shortest lag time of all terpenes tested (25). This is in contrast to fellow monoterpene d-limonene (almost identical, structurally, to l-menthol, with the exception of lacking the afore mentioned hydroxyl group) which has been shown to be much less effective for polar compounds (25, 27).
A second chemical is laurocapram. It too has been shown to be quite successful with polar drugs (23,28,29), likely due to its increasing the water content of the lipid phase of the stratum corneum. In one study, it enhanced the flux of mannitol in a propylene glycol vehicle by over 350 fold (23). In another, it enhance 5-fluorouracil delivery by 100 fold (29). Unfortunately, it displays a significant lag time -- meaning it can take as much as 10 hours before it starts to work (30, 31, 32). Consider most of us shower daily, this is not acceptable.
That brings us to n-methyl-2-pyrrolidinone (NMP). In combination with laurocapram, in a study using morphine hydrochloride, which has physical properties similar to Yohimbine Hydrochloride -- both polar molecules, molecular weight of 322 vs. 390 -- and is thus quite applicable, NMP was shown to significantly reduce the lag time (down to as low as 2 hours) as well as increase the rate of penetration for the drug as indicated by blood levels that were several THOUSANDFOLD higher than controls (32). In addition, it has been shown in several other studies to enhance penetration of polar molecules on its own, including a 256 fold increase with mannitol (23).
Another good candidate is glycerol, which provides dual functions. First, it helps to counter any skin irritation that might be caused by the alcohol carriers. This is due to its increasing the water content of the skin, and as alluded to in regards to laurocapram, this increase in water content has the added bonus of increasing penetration for polar molecules such as yohimbine (33, 34).
Other substances that are likely to be effective include various other pyrrolidones and derivatives (23, 35, 36), terpenes with hydroxyl groups, such as geraniol, 1,8 cineole, nerolidol (37, 38, 39) and Azone derivatives (40, 41).
Yohimbine vs. yohimbe
Quite a bit of confusion seems to exist about the difference between Yohimbine and yohimbe. Yohimbine is the principal alkaloid from the herb P. yohimbe. However, there are 31 other yohimbane alkaloids that can be present in herbal yohimbe preparations. Some of these have different and unknown selectivities and potencies (and thus, effects) at the adrenergic receptors (42, 43) -- in addition, these preparations vary greatly from brand to brand and even from batch to batch, as no standardization for extraction exists. In fact, a recent investigation found that most over the counter preparations have little to no actual yohimbine (44). And, even in the more potent preparations, most people find a higher degree of undesirable effects with the herb vs. pure Yohimbine (due to the afore mentioned 31 other yohimbane alkaloids that can be present). So, make sure and go a product that contains pure, pharmaceutical grade Yohimbine HCl, which will avoid the added side effects from other alkaloids - thus, allowing safer, more reliable dosing.
Dosing
Because some people are unusually sensitive to yohimbine, I would recommend that one start with a small dose -- 25-50 mg and then increase the dosage by 25-50mg each day until side effects become unacceptable. Dividing it into two doses would be ideal, but probably not necessary. Assuming the product is formulated properly, and delivery is localized to the adipose tissue, most people will be able to safely use very high doses -- 300+ mg/day.
Another thing to be considered when using yohimbine is that insulin blunts its lipolytic effects. Because yohimbine is not reaching the pancreas in significant amounts as it would with oral administration, insulin levels will not be as high for a given amount of carbohydrates, but they will still be elevated. Thus, it should ideally be used on a low-carb/ketogenic diet, or at the very least, one should do moderate aerobic activity for an extended period first thing in the morning on an empty stomach.
Conclusion
I think it should now be exceedingly clear that true "spot reduction" of bodyfat is indeed possible -- but it should also be clear that not all topical fat loss products are created equal. And, you should now be equipped to make an informed decision on which one to use.
To sum up:
The formulation should contain active ingredients that are significantly lipolytic rather than mere diuretics -- this rules out the aminophylline only products.
The formulation should use yohimbine hydrochloride rather than the yohimbe herb. Make sure the ingredients state "yohimbine HYDROCHLORIDE or HCl" not just "yohimbine".
nr 3:
WHAT IS YOHIMBINE HCL?
Yohimbine HCl is a synthetic copy of the active and effective alkaloid in yohimbe extract.
WHAT GOOD IS YOHIMBINE HCL?
Well, its main benefit is that it allows for the release of fatty acids from "stubborn" fat.
WHAT IS "STUBBORN" FAT?
Typically, so called stubborn fat is estrogenic in nature- though some people just have high #'s of A2 receptors- the A2 receptor is highly influenced by estrogen- if you are a women or have estrogenic fat patterns you most likely have large #'s of A2 receptors.
HOW DOES YOHIMBINE WORK?
It binds to the A2 and blocks Norepinephrine (and other A2 agonist INCLUDING ESTROGEN) from binding to and agonizing it (which inhibits the release of fatty acids)- thus it allows for fatty acids to be "burned" and thus stubborn fat to be lost.
WHERE DOES YOHIMBINE WORK BEST?
Best areas are typically thighs, triceps, love handles, glutes and chest. Though any area that has soft female fat is likely to have high concentrations of A2 receptors.
METHODS OF ADMINISTRATION
1. Take Yohimbine HCl powder topically if fat loss is your most important goal
2. Oral admin is more stimulatory- a small dose sublingually about 10-15min prior to workout can be very beneficial- much lower doses than topical.
3. Out partying or want to get really amped up Yohimbine HCl can be snorted -- though don't over do it, -- it will make you feel crappy.
LETS GET BACK TO TOPICAL AS FAT LOSS IS THE GOAL OF MOST.
A. Twice daily topical administration will give you the greatest benefits- though smaller more frequent dosing with varied sites may produce better results in some individuals.
B. Dosing will vary depending on tolerance, one scoop or 20mg (typically) per dosing is a good place to start though some can tolerate/enjoy much higher doses - you will know when you take too much as it will not feel good. (headache, tired, just unwell - nothing really bad just annoying)
C. The best sites for application as mentioned above are triceps, "love handles", thighs, glutes, calves, chest- basically any area that has fat accumulation- these areas will vary from individual to individual- though the above listed are the most common.
TIPS AND TRICKS- CARRIERS AND PENETRATION ENHANCERS
1. Apply after a hot shower
2. Use a body scrub to get rid of dead skin- this should be done 2-3 times a week
3. It may be of some benefit to swab the area with diluted alcohol prior to admin- though this is probably only really beneficial if not applying after a shower.
4. Use one or more carriers- depending on the site of application and sex- if you are older or a woman you will need less penetration as well
CARRIERS
a. Organic carriers- aloe vera, while aloe vera gel is effective, the use of pure liquid aloe vera is better and thus recommended. This carrier also hydrates the skin
b. Menthol either diluted (see oil list below) or in a cream base like Aspercreme (1%menthol) or Bengay (16%menthol) (which may itself have some localized effects- aspirin has been shown to inhibit oxidative phosphoralation) salycilic acid (aspirin is also a penetration enhancer). This category includes peppermint (50% l-menthol), wintergreen(50-70%) and spearmint oils(50-70%)- all of which are excellent carriers and penetration enhancers- if using oils be sure to dilute about 8 parts water or aloe vera to 1 part oil.
c. Capsicum- contained in several cream products (the more capiscum the better)- will increase absorption, may have some localized effect on fat burning. This may be too harsh for some- perhaps best diluted and added to other carriers.
e. Pluronic gel- aka phlogel- should only be used in areas with poor blood flow- as it will dramatically increase uptake. This is difficult to obtain and probably not worth the effort as similar results can be obtained cheaper and more easily.
POSSIBLE CARRIERS BUT NOT RECOMMENDED
f. Alcohol- that's right plain alcohol- which is what most of the topical prohormones use (it is gelled alcohol)- though this is better as a carrier for prohormones- it is not recommended for use with Yohimbine HCl except to clean the site prior to admin.
g. isopropyl myristate- a widely available, cheap, cosmetic ingredient ... Add this to alcohol and you have the same formula used in ANDRO-GEL- by Unimed Pharmaceutical- This option is also not recommended- though it is one that I looked into earlier it may be a alternative to DMSO with respect to finaplix)
*************
h. DMSO- this works well but may speed yohimbine too quickly into blood stream and makes your breath stink of garlic- it is a option for those who want to take a lower dose (high dose with DMSO may be unwise) and mix with crushed T3 tabs or triac (this is illegal- actually the use of DMSO as a carrier is illegal- so this is for informational purposes only) Though I think that topical use with other carriers and oral t3 use are more effective- but it is worth mentioning as some have gotten good results with this combo.
The best thing to do is to try these different carriers to find the ones that are right for you- the easiest to get are MENTHOL (Aspercreme, Bengay, peppermint oil-diluted) and aloe and perhaps swab the area with alcohol just prior- for most people this is sufficient to get good results. If you have large pockets of fat with little blood flow- i.e. these areas are always cold- then using stronger penetration enhancers is advisable. Women, because they have thinner skin, will probably need to use less penetration enhancers.
SOME Q&A
RESULTS?
Results will depend on the # of A2 receptors. A2 number is greatly affected by estrogen levels. If you have estrogenic fatty pattern- thighs chest and triceps- then it will be very effective as it is very effective for women.
WILL YOHIMBINE MAKE ME HOLD WATER?
Almost certainly- this water retention may take up to 2 weeks to dissipate if you have been running yohimbine topically for long periods and high doses.
HOW DO YOU CYCLE YOHIMBINE?
Yohimbine may be taken in a variety of ways though the most common and comfortable pattern, with less water retention, is 3-4 days on and 1-2 days off. However, it can be taken every day though with higher doses watch out for systemic build up.
WHO WILL BENEFIT MOST FROM YOHIMBINE USE?
1. Women
2. Men with female fat storage patterns
3. Men who have bulked heavily while on aromatics test/dbol- which because of the increase in estrogen will increase the number and sensitivity of A2 receptors.
4. Men who are very lean and trying to drop those last few "stubborn pounds" - typically in thighs, lower back, and love handles.
WILL YOHIMBINE HELP TO GET RID OF FATTY GYNO?
Yes, though it will do NOTHING for the fibrous mass (true gyno). Concurrent use of Arimidex (prescription) and pgf2a (not approved in humans)- may be the most effective stack.
WHAT STACKS WELL WITH YOHIMBINE?
ECA- may be too stimulatory
CLEN- drink lots of water
DNP- almost a necessity
NCY- enhances
nr 4:
How is Yohimburn applied?
It is applied directly to the area where you have stubborn fat pockets. You use the pipette to squirt a measured amount onto the skin, which you then rub in.
Is there anything that I need to do to prepare my skin for the application?
1. you should exfoliate the area, at least 2 to 3 times per week. Exfoliation gets rid of the dead surface layer of skin that may hinder your results.
2. you should apply to clean skin, usually after a shower. If not applying after a shower, just rub the application site with a warm wet cloth or rag.
How much should I apply?
This really varies a lot. People’s response and tolerance to Yohimbine varies. Generally, most people use between 3/4 and 1 full pipette per application. This equates to roughly 60-80mg. However, when beginning your treatment with Yohimburn you should start with a quarter pipette per application and work you way up to a comfortable dose. If you start to notice side effects; which include headache, chills, or excessive tiredness... you are taking too much. Most people don't experience these effect until well over 1 pipette. Some people can apply two or three pipettes without any side effects. These are just general guidelines, you must decide what is too much or too little for you.
HOW MANY SERVINGS OR APPLICATIONS ARE THERE IN A BOTTLE?
There are approximately 150 quarter pipette servings
There are approximately 75 half pipette servings
There are approximately 38 full pipette servings.
Each bottle contains 3100mg of Yohimbine.
Each bottle contains 105ml of solution.
Each quarter pipette contains 20-22 mg of Yohimbine.
Each quarter pipette contains approximately .7ml.
S O HOW LONG WILL A BOTTLE LAST ME?
It really depends on how much you use and the frequency of use but a bottle typically last 4-6 weeks, especially if using the 4-5 ON / 1-2 OFF pattern of use, described below. But it can last longer if you are just using on small areas or shorter if you like using higher doses or don't use the ON/OFF pattern.
How often should I apply Yohimburn?
Once or twice a day. Though some people like to apply it more often. When applying more often you must be aware of the fact that Yohimbine builds up in your system and the above side effects may “sneak” up on you with more frequent dosing. Some people like to dose more frequently, but if you do just keep this in mind.
CAN I APPLY IT EVERY DAY?
Yes . But we recommend that it be applied 4 to 5 days ON and then 1-2 days OFF. This pattern allows for higher doses and helps with both systemic build up and the water retention that sometimes accompanies Yohimburn use. Many people use it for weeks straight and really enjoy taking it this way. However, most people generally feel better with this ON/OFF pattern of use and the results are more apparent on the days off.
HOW LONG UNTIL I SEE RESULTS?
It varies and depends upon a lot of factors. The three main factors are diet, exercise and water retention. But results can been seen in as little as 5 days of use. However, the BEST picture of results is after you stop using Yohimbine and what water retention, if any, you have recedes. This can take up to 2 weeks, but usually any excess water is gone by a week after cessation.
ARE THE RESULT PERMANENT OR JUST TEMPORARY?
The results are "permanent" loss of fat, not just temporary losses of water which is sadly the basis for many fat loss products. The permanent is in " " because as with any fat loss if you overeat or are exposed to the same biochemical environment, usually in conjunction with the overeating, fat can return. But is as permanent as any other fat loss. In another section we will deal with managing estrogen, which is important for both men and women
Hvis noen trenger litt lipoderm-y, send meg en mail(fina@elitefitness.com)
mvh
HIT
WHAT IS THE RIGHT DOSAGE FOR ME?
DOSAGE- this is very individual- the only dosage recommendation that I give is start with 20-40mg per application and work your way up- 2-3 applications per day- and use different sites during the same day- i.e. don't do thighs twice in the same day.
Svar med sitat
Opprinnelig skrevet av NK 
may be protective against yohimbine toxicity.
