Tråd: Ursolic acid: AI, kortisolhemmer og anabolt?

Jeg har siden årsskiftet brukt moderate doser av UA tre ganger daglig, iløpet av en måned er jeg blitt 3kg tyngre og mistet fett. Mens jeg har benyttet meg av IF og i overkant høy treningsmengde. Jeg mistenker at tilskuddet kan ha hatt effekt, jeg har i tillegg brukt DAA men blodprøvene avdekker at testosteronnivået mitt ikke er noe å rope hurra over.

UA presenteres i enkelte artikler som et svært lovende tilskudd spesielt mtp. kreftforskning osv. Hva tror ekspertpanelet?

Noen utdrag fra artikler jeg har funnet:

Kreft: Ursolic acid (3β-hydroxy-urs-12-en-28-oic acid) was identified to inhibit the cell-surface ICAM-1 expression induced by pro-inflammatory cytokines in human lung carcinoma A549 cells. Ursolic acid was found to inhibit the TNF-α-induced ICAM-1 protein expression almost completely, whereas the TNF-α-induced ICAM-1 mRNA expression and NF-κB signaling pathway were decreased only partially by ursolic acid
Biomolecules | Free Full-Text | Ursolic Acid Inhibits Na+/K+-ATPase Activity and Prevents TNF-?-Induced Gene Expression by Blocking Amino Acid Transport and Cellular Protein Synthesis

IGF-1: The researchers from Iowa stumbled upon the anabolic properties of ursolic acid when they were examining cells from muscle tissue that was wasting. They determined which genes in the cells were active during the process of muscular atrophy. Then they searched databases for substances that had precisely the opposite effect. The most promising substance that they found was ursolic acid.


The researchers gave this to fasting mice and observed that the ursolic acid led to a reduction in the processes of muscle atrophy. They then did a second round of experiments, in which the mice were given as much to eat as they wanted. A control group was given ordinary feed and another group was given feed containing 0.27 percent ursolic acid.


The figures immediately below show that a five-week course of malol resulted in growth of the quadriceps and that the mice grew stronger. The activity of the catabolic genes MuRF-1 and Atrogin-1 declined in the muscle cells. In contrast, the activity of the gene for IGF-1 increased, as did the concentration of IGF-1 in the blood. Molecular signalling molecules, like the receptor for IGF-1, Akt and S6K, were switched on.

The researchers suspect that ursolic acid's prime target is the IGF-1 receptor. This becomes more sensitive and as a result the IGF-1 that is present in the body works better.
http://www.ergo-log.com/ursolicacid.html

Ursolic Acid is believed to:

Reduce fat storage and increase fat burning, through inhibition of pancreatic lipase and enhanced lipolysis in fat cells. [1]

Reduce the conversion of blood sugar to fat, through inhibition of fatty acid synthase. [2]

Increase energy reserves in muscles by enhancing glycogen storage. [3]

Reduce abdominal (visceral) fat through the inhibition of 11bHSD1. [4]

Be anti-carcinogenic through inhibition of the STAT3 activation pathway. [5]

Lower cholesterol through the activation of peroxisome proliferator-activated receptor (PPAR)-α. [6]

Reduce estrogen levels through aromatase inhibition. [7]

Strengthen bones by enhancing differentiation and mineralization of osteoblasts. [8]

Increase lean muscle mass through enhanced sensitivity to IGF-1 and insulin and inhibition of atrogin-1 and MuRF1. [9]

Høres interessant ut. Hvor får man tak i dette?

Foreløpig er det bare E-pharm som selger det i form av et produkt kalt Ursobolic. Predator har det, men ifølge AM og andre forumer jeg har lest på er det visst mye å spare på å handle i bulk fra US-sjapper, også for oss i Europa om man tar sjangsen på det.

Researchers have discovered that ursolic acid – a substance found in the peel – has natural body building qualities and could help people keep a toned, slender body.


It could even help with diabetes.


In experiments they discovered that it boosts muscle growth by up to 15 per cent and reduces body fat by more than a half.


It also has health giving properties – reducing blood sugar levels, cholesterol and harmful fatty acids, according to the new study.


Dr Christopher Adams, the study leader at the University of Iowa, said the substance could be especially useful in the elderly who naturally lose body muscle, known as atrophy.


"The old saying goes that 'an apple a day keeps the doctor away'," he said.

"Muscle atrophy causes big problems. It's also very common – it affects most people at some point in their lives, during illness or ageing. But, there's no medicine for it.

"We studied muscle gene activity in people with atrophy and used that information to find chemicals that might block atrophy.

"One of those chemicals was especially interesting. It's called ursolic acid and it's particularly concentrated in apple peels."

The study, published in the latest issue of the journal Cell Metabolism, showed that ursolic acid reduced muscle wasting in mice.

They believe the substance works by reprogramming genes that cause muscle wasting and fat build up.

"Interestingly, although ursolic acid increased muscle weight in mice, it did not increase total body weight, and further investigation showed that mice fed ursolic acid had less body fat than mice that were not fed the compound," he said.

Now they plan to try it on humans to see if it has the same effect.

An apple a day keeps your body toned and slender - Telegraph

Abstract

The inhibitory potency of ursolic acid extracted from Ilex paraguariensis, a plant used in South American population for a tea preparation known as maté, and its derivatives to inhibit aromatase activity was assessed and compared to a phytoestrogen apigenin and a steroidal aromatase inhibitor 4-hyroxyandrostenedione (4-OHA). Among all compounds tested only ursolic acid 1 showed an efficient and dose-dependent aromatase inhibition with IC50 value of 32 microM as did apigenin (IC50=10 microM), whereas IC50 value of 4-OHA was 0.8 microM. Our results show that the incorporation of a metallocene moiety into the ursolic acid derivatives decreases the aromatase inhibition. Moreover, comparison of the structure/inhibitory potency relationship of compounds indicates that the presence of cycle A and the configuration of C3-OH and C17-COOH seems to be more favourable to recognize the active site of aromatase and to block its activity.

Evaluation of ursolic acid isolated from Ilex... [Eur J Med Chem. 2008] - PubMed - NCBI

Jeg har lyst til å tro på dette tilskuddet og bestilte nettopp to bokser til sammen med pes Erase og DAA.
De kreftforebyggende og aromatasehemmende egenskapene virker å være svært godt dokumentert. De anabole egenskapene er visstnok ikke testet på mennesker, så jeg tar en for laget og tester det.

Opprinnelig skrevet av metromeno

Foreløpig er det bare E-pharm som selger det i form av et produkt kalt Ursobolic. Predator har det, men ifølge AM og andre forumer jeg har lest på er det visst mye å spare på å handle i bulk fra US-sjapper, også for oss i Europa om man tar sjangsen på det.

Det finnes et "husmerke" som heter Jacked og produktet heter Ursobol. Den er sterkere/billigere enn Ursobolic fra E-pharm. Jeg har 6 bokser med E-pharm Ursobol hjemme, venter på at jeg skal skjerpe meg før jeg begynner-..

Takker for tipset, btw er den fra jacked samme dosering. 600mg totalt ekstrakt, på e-pharm er det definert at 150 av de 600 er ren ursolic acid. Det er ikke angitt på den fra jacked.

mad props bros. m04r av sånt!!

Det blir lite snurrigt för vissa, därför skall jag försöka förtydliga..

U-Grow per 6 kapslar (120st kapslar per burk)
Fructus Ligustri Lucidi extrakt 1200 mg
Varav aktiv Ursolic Acid 300 mg

E-Pharm Ursobolic per 6 kapslar (120st kapslar per burk)
Loquat extrakt 1200 mg
Varav Ursolic Acid 300 mg

JACKED Ursobol per 6 kapslar (120st kapslar per burk)
Loquat extrakt 3600 mg
Varav Ursolic Acid 900 mg

Patric Arnold E-Pharm Ursobolic samt Jacked Ursobol har valt Loquat extrakt 25% medan U-Grow har valt Fructus Ligustri Lucidi extrakt 25%.

JACKED Ursobol innehåller 3ggr/300% mer Ursolic Acid per burk än U-grow och E-Pharm Ursobolic.

Nu hoppas jag att det är lite lättare att förstå alla parametrar.
Tydligen har det varit snurrigt för en del personer som kontaktat mig.

Opprinnelig skrevet av metromeno

[I]

Dr Christopher Adams, the study leader at the University of Iowa, said the substance could be especially useful in the elderly who naturally lose body muscle, known as atrophy.

"The old saying goes that 'an apple a day keeps the doctor away'," he said.

"Muscle atrophy causes big problems. It's also very common – it affects most people at some point in their lives, during illness or ageing. But, there's no medicine for it.

(Hvis man ser bort i fra bivirkninger, så har jeg en mistanke om at dette kunne funket)

Btw, her er Ergo-Logs omtale av Ursolic Acid:

Ursolic acid: apple anabolic

Ganske greie og lesbare artiklene på ergo-log, står ikke så mye nytt men fine å lese

Fra medisinskapet ditt McBain?

Opprinnelig skrevet av Platon73

Fra medisinskapet ditt McBain?

Garantert om det ikke var for at jeg gjerne vil bli mer enn 30 år gammel samt bli far en gang i løpet av de neste årene

ja det er ingen av de som bruker sånn som er over 30 og far lol.

Kun Arnold som er unntaket